Name | inositol niacinate |
Synonyms | dilcit dilexpal inositol niacinate INOSITOL NIACINATE INOSITOL NICOTINATE Inositol Nicotinate INOSITOL HEXANICOTINATE Inositol Hexanicotinate MYO-INOSITOL HEXANICOTINATE myo-inositol hexanicotinate inositol hexa-3-pyridinecarboxylate MYO-INOSITOL HEXA-3-PYRIDINECARBOXYLATE cyclohexane-1,2,3,4,5,6-hexayl hexapyridine-3-carboxylate |
CAS | 6556-11-2 |
EINECS | 229-485-9 |
InChI | InChI=1/C42H30N6O12/c49-37(25-7-1-13-43-19-25)55-31-32(56-38(50)26-8-2-14-44-20-26)34(58-40(52)28-10-4-16-46-22-28)36(60-42(54)30-12-6-18-48-24-30)35(59-41(53)29-11-5-17-47-23-29)33(31)57-39(51)27-9-3-15-45-21-27/h1-24,31-36H |
Molecular Formula | C42H30N6O12 |
Molar Mass | 810.72 |
Density | 1.3348 (rough estimate) |
Melting Point | 254-256°C(lit.) |
Boling Point | 755.54°C (rough estimate) |
Flash Point | 496.3°C |
Solubility | Aqueous Acid (Slightly, Heated), DMSO (Slightly, Heated, Sonicated) |
Vapor Presure | 6.9E-33mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
Merck | 13,5002 |
pKa | 3.92±0.10(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.6400 (estimate) |
Use | Hypolipidemic drugs, can reduce cholesterol and dilate peripheral blood vessels |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 2 |
RTECS | NM7535400 |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Introduction | the chemical name of inositol nicotinate is hexonicotinate-cis -1,2,3,5-trans -4,6-cyclohexane, also known as inositol nicotinate, nicotinyl Ester, inositol nicotinate, inositol hexanicotinate, xinxuetong injection, etc., has the effect of reducing cholesterol and dilating peripheral blood vessels, it can be used to treat hypercholesterolemia and atherosclerosis. Clinically, it is now used for the adjuvant treatment of hyperlipidemia, coronary heart disease, various peripheral vascular disorders (such as arteriosclerosis obliterans, acral arterial spasm, frostbite, vascular migraine, etc.). |
Application | for the adjuvant treatment of hypertension, atherosclerosis and various peripheral vascular disorders. |
pharmacological effects | after absorption from the gastrointestinal tract, the drug is slowly metabolized in the body and gradually hydrolyzed to niacin and inositol, then play a role through both. It can relax and permanently relax peripheral blood vessels, improve abnormal lipid metabolism, dissolve fibrin, dissolve thrombus and anticoagulation. The indication of hyperlipoproteinemia is the same as niacin, which can be used as adjuvant therapy. And can be used for coronary heart disease and a variety of peripheral vascular spasm disease (such as arteriosclerosis obliterans, acral arterial spasm, migraine, etc.) adjuvant therapy. |
Clinical application | inositol nicotinate is a mild peripheral vasodilator, which can reduce cholesterol and dilate peripheral blood vessels, it is an adjunctive drug and nutritional food additive for hypercholesterolemia and atherosclerosis. Inositol nicotinate is gradually hydrolyzed into nicotinic acid and inositol in vivo, so it has the pharmacological effects of both nicotinic acid and inositol. Inositol nicotinate has a lipid-lowering effect, and its vasodilator effect is more mild and lasting than niacin, without side effects such as flushing and stomach discomfort after taking niacin. |
Usage | hypolipidemic drug, which has the effects of lowering cholesterol and dilating peripheral blood vessels hypolipidemic drug, it has the effect of lowering cholesterol and dilating non-slight blood vessels. Biochemical Study |